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Table of Content Volume 1 Issue 1 - January 2017

 

Effect of single dose of Di isobutyl Phthalate on hepatic development in Wister rats treated prenatally

 

Shetty PN1, Ray B2, D’Souza AS3, Sushma RK3, Nayak D4, Rao ACK5,Chakraborti S6

 

1Department of Anatomy, Manipal College of Medical Sciences, Pokhara, NEPAL.

2Department of Anatomy, ESICMC - PGIMSR, Rajajinagar, Banglore, Karnataka, INDIA.

3Department of Anatomy, Kasturba Medical College, Manipal, Karnataka, INDIA.

4Department of pharmaceutical chemistry ,Manipal college of Pharmaceutical sciences ,Manipal ,Karnataka, INDIA.

5Departmentof Pathology International Centre, Manipal, Karnataka, INDIA.

6Department of Pathology, Kasturba Medical College, Manglore, Karnataka, INDIA.

Email: dr.prasadnshetty@gmail.com

 

REFERENCES

  1. Metcalf RL, Booth GM, Schuth CK, Hansen JJ and Lu PY. Uptake and fate of di-2ethylhexylphthalate in aquatic organisms and in a model eco-system. EnvironHealth Perspect.1973; 3: 27-34.
  2. ShibkoSIand Blumenthal H.Toxicology of phthalic acid esters used in food packaging material. Environ Health Perspect.1973; 3: 131-137.
  3. William M. Kluwe. Phthalate Ester Pharmacokinetics in Mammalian Species, Overview of Environmental Health Perspectives.1982;45: 3-10
  4. Cerbulis, J and Ard, JS. Methods for isolation of di-octylphthalatefrom milk lipids. J. Assoc. Off. Anal.Chem. 1967; 50: 646.
  5. Sonia Hernández-DíazAllen A, MitchellKatherine E, KelleyAntonia M,Calafatand Russ Hauser.Medications as a Potential Source of Exposure to Phthalates in the U.S. Population.2009; 2:117.
  6. The Consumer Product Safety Improvement Act of 2008 (CPSIA). International Coatings screen print ink products marked "Phthalate Compliant" or "Non-Phthalate" comply with the lead and phthalate, U.S.Title 16 CFR Part 1303. www.cpsc.gov/cpsia.pdf.
  7. BaarsAJ,Thealen RMC, JanseenPJC, HesseJM et.al .National institute of public health and environment, RIVM report 711701025 on phthalate .2001:134-297.
  8. IPCS, CIC (International Programme on Chemical Safety, Commission of the European Communities. (2001) Diisobutyl phthalate (International Chemical Safety Card 0829) (http://www.inchem.org/documents/icsc/icsc/eics0829.htm).Accessed October 2006)
  9. Adibi JJ, Whyatt RM, Williams PL et al.. Environmental health perspectives on Pthalate.2008; 116 (4):467.
  10. Saillenfait AM, Sabaté JP, andGallissotF.Developmental toxic effect of Diisobutylphthalate. The methyl-branched analogue of di-n-butyl phthalate Toxicology. 2006; 165: 39-46
  11. Report on carcinogen.National Toxicology Programme, Department of Health and Human Services. 2011; 12:156-158.
  12. Arnold Schecter,MatthewLorber, YingGuo, QianWu, SeHunYun et.al. Phthalate Concentrations and Dietary Exposure from Food Purchased in New York State.2013;4:121.
  13. Eastman Kodak Company.Toxicity and health hazard summary, diisobutyl phthalate. 1978 OTS 0206525. DOC #878214402. Internet resource.
  14. National Industrial Chemicals Notification and Assessment Scheme.(NICNAS)Di Isobutyl Phthalate, Existing chemicals hazards assessment report .June2008. Australian Government of Health and Aging. Sydney. NSW. Australia. WWW.nicas.gov.au.
  15. Singh AR, Lawrence WH andAutian J. Teratogenicity of phthalate esters in rats. Journal of Pharmaceutical Sciences. 1972.
  16. Hodge HC. Preliminary acute toxicity tests and short term feeding tests of rats and dogs given diisobutyl phthalate and dibutyl phthalate. US,EPA/OPTS public files. 1954.
  17. Borch J, Axelstad M, Vinggaard AM andDalgaard M. Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in foetal rat testis. Toxicology Letters, 2006; 163: 183-190
  18. OishiS andHiraga K. Effects of phthalic acid monoesters on mouse testes. Toxicology Letters.1984; 6: 239-242.
  19. ParkhieMR,Webbt TM and Norcross MA.Dimethoxyethyl Phthalate: Embryopathy,Teratogenicity, Fetal Metabolism and the Role of Zinc in the Rat.Environmental Health perspectives .1982; 459:89-97.
  20. Elsisi AE, Carter DE and Sipes, IG. Dermal absorption of phthalate diesters in rats. Fundamental and Applied Toxicology.1989;12:70-77
  21. Swan S, Main K, Liu F, Stewart S, Kruse R, Calafat A, Mao C, Redmon J, Ternand C, Sullivan S, Teague J. The-Study-for-Future-Families-Research-Team, Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect. 2005;113:1056-1061
  22. Istituto di Ricerche Farmacologiche “Mario Negri”, Via Eritrea, International Agency for Research on Cancer (IARC). IARC Monographs on the evaluation of the carcinogenic risk of chemicals to humans .1982; 29: 269-294.
  23. Gray TJB ,Butterworth KR, Gaunt IF, GrassoP and Gangolli SD. Short term toxicity study of di (2 ethylexyl phthalate in rats. Food Cosmet. Toxiocol.1977; 15:389-399.
  24. Tomita L, Nakamura,Y and Yagi Y.Phthalic acid esters in various food (NICAN) NATIONAL INDUSTRIAL CHEMICALS NOTIFICATION AND ASSESSMENT SCHEME Australian govt (2008). Existing Chemical Hazard Assessment Reporteffects and biological materials. Ecotoxicoal Environs. Safety ,1979;1:275-278.
  25. Ganning AE, Brunk U and Dallner G.Phthalate Esters and Their Effect on the Liver. Hepatology.1984; 4: 541–547.
  26. Seth PK .Hepatic effects of phthalate esters. Environmental health perspectives, 1982; 45:27-34.
  27. MelnickRL.International journal of occupational and environmental health.2002;8 : 284-286.
  28. Lee KY, Shibutani M, Takagi H, Kato N, Takigami S, Uneyama C, et al.. Diverse developmental toxicity of di-n-butyl phthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation.Toxicology.2004;38:203:221.