Abstract              Background: Carpal tunnel syndrome (CTS) is the most commonly-encountered entrapment neuropathy and routinely seen mononeuropathy in busy neurology out patients departments. There is a need to study the clinical features and associated factors in greater precision as it is a readily treatable disorder with excellent treatment outcomes. Aims and Objectives: To study clinical profile and factors associated with Carpel tunnel syndrome. Methodology: This is a cross-sectional study done in patients presenting with clinical features of CTS at tertiary health care center during the year January 2015 to January 2016. The detailed clinical and electrophysiological examination was done. Stevens’s severity scale was used to classify as per the severity. The patients cohort were later divided in two groups ;those fulfilling clinical and electrophysiology criteria for CTS(Group 1) and those who are having just wrist pain due to other etiology (Group 2).The appropriate statistical tests were used to compare associated factors in both the groups. Results: Total of 240patients was included.128 patients were fulfilling clinical and electrophysiology criteria for CTS and 112 patients were of nonspecific wrist pain only. In this study, female preponderance was seen with majority in the age group of 30-45(40.63). The exacerbations of pain at night occurred in 95.00%. The pain and tingling in thumb, middle and index fingers occurred in 90.63% and that in entire arm was seen in 65%. The Motor weakness involves Abductor pollicis brevis in 46.88 % patient. Tinels sign (50%); Phalens test (65%) Tourniquet test was positive in 85%.The significantly associated factors were Female sex, Acute, severe flexion/extension injury of wrist, Obese (BMI> 30), Diabetes. Conclusion: General neurologists and physicians should keep suspicion of this common neuropathy in obese females of older age groups with associated risk factors like diabetes, hypothyroidism and arthritis. The clinical features described in this study will help in more precise diagnosis of this ubiquitous disorder.

Key Words: Carpel tunnel syndrome, Hypothyroidism, Diabetes, Rheumatoid arthritis.