Abstract              Objective: To compare any differences in the lipid profile of untreated schizophrenia patients, treated schizophrenia patients and their first degree relatives. Methodology: The Study is conducted among untreated schizophrenia patients, treated schizophrenia patients and their first degree relatives who came to Mamata general hospital, Khammam. Total study sample consists of 90 out of which there are 30 treated schizophrenic patients, 30 untreated schizophrenic patients and 30 first degree relatives of either group who were randomly selected. Estimation of Triglycerides by Enzymatic Colorimetric Test: (GPO/PAP method). Results: Mean triglycerides was significantly higher in treated schizophrenics compared to untreated schizophrenics and FD. There was significantly higher rate of hypertriglyceridemia in patients treated with anti-psychotics when compared to drug naive and first degree relatives. There were no significant differences in rate of hypertriglyceridemia between FDR and drug naive patients. Conclusion: Use of second generation anti-psychotics in schizophrenia patients significantly affects lipid profile, which increase triglyceride levels abnormally.

Key Words: Anti-psychotics, schizophrenia, lipid profile, triglycerides.