Abstract              Background: Nephrotic syndrome is defined as proteinuria 3 gms/24 hrs or more associated with spot urine albumin creatinine ratio of more than 300-350mg/mmol, sr.albumin <25g/l with evidence of peripheral edema with hyperlipidaemia This study was carried out to study clinical and etiological profile of nephrotic syndrome in adults including geriatric patients and by establishing diagnosis by renal biopsy wherever indicated and to assess the response to the treatment. Methodology: It was a prospective observational study carried out in patients admitted at a tertiary care centre. Result: This study comprised of total 84 patients with nephrotic syndrome and had male preponderance, minimal change disease (MCD) was the most common cause comprising 12 (18.18%) cases followed by focal segmental glomerulosclerosis (FSGS) 11 (16.16%) cases followed by 10 (15.15%) cases of membranous glomerulonephritis (MGN) followed by 5 (7.57%) cases of DPGN(diffuse proliferative glomerulonephritis) followed by 4 (6.06%) cases of IGAN(IgA nephropathy) followed by FPGN(focal proliferative glomerulonephropathy) and RPGN (rapidly progressive glomerulonephropathy) 2 (3.03%) cases of each followed by one case each of C3 glomerulopathy and PSGN.

Key Words: nephrotic syndrome.