Study of prevalence of insulin resistance in non-diabetes hypertensive patients attending medicine OPD at a tertiary care center

 

K V Giriraja¹, Madhusudan C^2*

 

 

Abstract              Background: The patients with essential hypertension are increasing all over the world. There may be development of insulin resistance and hyperinsulinemia in essential hypertension. An association between essential hypertension and defective insulin secretion has been identified. Insulin resistance is the fundamental defect in the development of type 2 diabetes mellitus, hypertension and cardiovascular diseases. Objectives: To study the prevalence of insulin resistance in non-diabetes hypertensive patients Material and Methods: A total of 100 patients were taken, 50 each were divided into cases and controls. Appropriate investigations were done. Insulin resistance was determined by HOMA-IR (homeostasis model assessment of insulin resistance). Results: Statistically, the mean value of HOMA-IR in cases was 3.9 ± 1.92 and in healthy group was 2.1 ± 0.7 with p<0.05. Also study found waist circumference, BMI, FBS, TG, fasting plasma insulin showed significant association in hypertension group subjects Conclusions: Essential hypertension is significantly associated with higher mean fasting insulin levels and insulin resistance. Hyperinsulinemia has a possible role in the pathophysiology of essential hypertension with significance with BMI, insulin resistance being the likely predominant mechanism.

Key Words: Insulin resistance, essential hypertension, metabolic syndrome.