Role of hsCRP as an indicator of prognosis in acute coronary syndrome

 

Ashok Thaned¹, Triveni Ayyanna^2*, Sunil K³

 

Abstract              Background: Acute coronary syndromes (ACS) has become the leading cause of death worldwide. Inflammation plays an important role in ACS. C- reactive protein is a prototypical acute phase reactant, whose levels are increased proportional to the extent of inflammation. This study is done to measure high sensitivity c-reactive protein levels (hsCRP) in patients of acute coronary syndrome and determine its significance in prognosis. Methods: 100 patients with acute coronary syndrome(STEMI and NSTE-ACS) were included in the study. Serum high sensitivity c reactive protein (hsCRP) was measured at admission. Patients were followed up in hospital for mortality and complications.Results: STEMI was seen in 76 patients and 24 patients had NSTE-ACS.The hsCRP levels were increased in 76 patients out of 100 patients of ACS.Patients with high hsCRP at admission (=>3mg/L)are prone for going into complications(n=54) out of 60 patients (90%)(p<0.01). Conclusion: hsCRP levels obtained at admission can be used as a marker for identification of patients who are likely to develop significant complications in the immediate in-hospital course and to predict the prognosis.

Key words: STEMI, NSTE-ACS, ACS, hsCRP, inflammation, prognosis.