A study of LDL-C among patients with hypothyroidism at tertiary health care centre

 

Vijay Babu¹, Nagasumanth Reddy², Apsara³

 

Abstract              Background: Thyroid dysfunction has been implicated as to be have a great impact on lipids as well as a number of other coronary artery diseases. Community based studies have shown that subclinical hypothyroidism (SCH) is an independent risk factor for atherosclerosis (OR = 1.9). Objectives: To find out association between hypothyroidism and LDL-C levels at a tertiary care centre. Material and Methods: An observational study was done on 25 euthyroid and 75 hypothyroid cases. 75 cases divided into 3 groups equally as per levels of TSH hormone. LDL-C was evaluated after 1 year follow up. Data entered in excel and analyzed using SPSS version 20. ANNOVA test was used. Results: Women (68%) formed majority of study population, rest 32% was formed by males. Most common(41%) age group was 20-30 group, 31-40 age group formed 34% of the study population. Findings of T3 and T4 hormone were as per expected for hypothyroid patients in the study groups. while T3 and T4were 1.2±03and 6.8±1.6 respectively in group I (euthyroid) cases. LDL–C level mean±SD in group I was 96.4±5.2, group II was 120.9±4.9, group III was 133.4±3.7, group IV was 195.2±18.3. LDL C level was significantly (p˂0.05) associated with hypothyroidism in present study. Conclusions: Middle aged women most common age group. Hypothyroidism and higher LDL-C levels were significantly associated in this study.

Key Word: LDL-C, Hypothyroidism, TS