A Study of Fasting and Postprandial Lipid Profile in Patients with Type II Diabetes Mellitus

 

 

Abstract              Background: DM is a common secondary cause of hyperlipidemia, particularly, if glycemic control is poor, which in turn is an important risk factor for atherosclerosis and coronary heart disease. Aim: To study fasting and postprandial serum lipid profile in type 2 diabetes mellitus patients. Material and Methods: This was a prospective observational study in which 200 patients with type 2 diabetes mellitus. Fasting and postprandial lipid profile which included serum total cholesterol, serum triglycerides, LDL cholesterol, HDL cholesterol and VLDL were estimated in all the patients on semi-automatic analyzer. Results: There was increase or rise of values of TC, TG, VLDL in post prandial state when compared with fasting lipid profile. The rise or increase in TG and VLDL values is statistically significant. It was also noticed that the low values of HDL and LDL cholesterol in post prandial state when compared to fasting lipid profile. This was statistically significant in case of HDL cholesterol only. Conclusion: Lipid profile was significantly elevated in the postprandial state as compared to fasting state in the Type 2 DM patients. Routine estimation of the postprandial lipid profile, rather than the fasting lipid parameters is advisable in the cardiovascular risk assessment in Type 2 DM.

Key Word: Type 2 diabetes mellitus, lipid profile, Serum cholesterol, Serum triglyceride, Serum LDL