Spectrum of diabetic nephropathy in type II DM

 

 

Abstract              Diabetic nephropathy is the leading cause of chronic kidney disease in patients starting renal replacement therapy and is associated with increased cardiovascular mortality. Diabetic nephropathy has been classically defined by the presence of proteinuria >0.5 g/24 h. This stage has been referred to as overt nephropathy, clinical nephropathy, proteinuria, or macroalbuminuria. Methods: In this prospective study, 50 patients diagnosed diabetics were studied. Group A had 25 patients with at least one risk factor are hypertension, hypercholesterolemia and obesity. Group B had 25 patients without any of the risk factors. Patients who were selected for presence of Diabetic nephropathy with abnormal serum Creatinine, creatinine clearance and urinary albumin levels. Results: As many as 8 out of 50 patients were found to have Diabetic nephropathy. The number was significantly higher in group A compared to group B. Incidence of nephropathy was higher with higher number of associated risk factors. Urinary microalbuminuria was the commonest abnormality, Serum creatinine was found in only 25.84% of total positive cases. Conclusions: Hypertension, obesity and hypercholesterolemia can contribute to development of nephropathy, and also, urinary microalbuminuria appears to be much more sensitive than serum creatinine.

Keyword: type II DM.