Comparative analysis of bio chemical profile of complications in patients with acute febrile illness

 

 

Abstract              Background: The objective of this study was to compare bio chemical and clinical profile and to outcome of acute febrile illness complication in patients of tertiary care hospital during pre-winter season. Methods: it’s an observational and prospective study done in a Teerthanker medical college Moradabad, India. During the period of august 2018 to Nov 2018, patients admitted with complicated acute febrile illness were included. Patients were compared on the basis of demography, bio chemical profile of complication. Results: total of 275 patients were enrolled in which 186(66.8%) were males and larger proportion of the study comprises of cases with age group below 35yrs. On examination, mostly patients complained 0f generalized body ache (86.9%), headache (78.4%), nausea vomiting (72.4%), abdomen pain (52%), dark colored urine (36.2%), and dyspnoea (33.1%), loose stools (28.1%) and altered Sensorium (8.%). Significantly associated clinical sign were pedal edema 14.5% (P=0.001), icterus 20.7 % (P=0.0001) and tachypnea 19.4% (P=0.001). commonest complication of dengue at presentation was shock (70.9%) later on by hepatic (67.5%) and hematology (65%) derangements, that of malaria was acute renal failure (3.4%), followed by respiratory distress (22.3%). Overall mortality in Dengue was 7(3.8%), malaria 15(32.6%), Hepatitis E 2(50%). Conclusion: study shows similar spectrum clinical features, although there is diversity of etiology and causes that demonstrates the diagnosis complexity and thus treatment of acute febrile illness.so study of biochemical profile of complication in febrile illnesses will be a help to decrease morbidity and mortality because of post monsoon illnesses by early diagnosis and prompt treatment. Dengue and malaria emerges as the commonest causes and main killers because of respiratory and renal involvements.

Key Word: acute febrile illness, bio chemical profile, complications.