High sensitivity C-reactive protein vs quantitative Troponin-I as a prognostic marker in acute myocardial infarction

 

Anand Gaurav¹, Kaushal Kishore^2*

 

Abstract              Background: Acute myocardial infarction (AMI) is a major public health problem among the non communicable diseases in the developing countries like India, inspite of progressive research in diagnosis and management over the last three decades. Inflammation plays an important role in the AMI. An acute phase response C-reactive protein (CRP), is a marker of inflammatory activity and is associated with atherosclerosis and increased incidence of coronary events. Cardiac troponins are regulatory proteins within the myocardium that are released into the circulation when damage to the myocytes has occurred. Cardiac troponins has also been proven to be a potent, independent indicator of recurrent ischemic events, and an estimate for the risk of death among patients presenting with ACS. Methodology: It was observational study, it was performed at Patna Medical College, Patna, Bihar. All patients were collected from the department of Medicine IPD and to be tested in the department of central pathology based on clinical diagnosis. 60 Patients of Acute myocardial infarction, and the age group of 20-70 years was taken. Total study duration was 12 months from June 2018 to May 2019. Results: Majority of patients i.e. 66.6% patients belonged to 51-60 years in age group, ST segment elevation and Q wave myocardial infarction and Non ST segment elevation and Non Q wave myocardial infarction 58.3% and 47.1% in AMI patients found respectively. we have found significant correlation between LVIDs, EF and hsCRP. Conclusion: Both biomarkers is very important diagnostic tool of in acute myocardial infarction detection. hsCRP was positive correlation with IVS and Trop-I. hsCRP have more sensitivity than Trop –I, Trop-I have more specification compare to hsCRP.

Key Word: Troponin-I