Table of Content Volume 15 Issue 2 - August 2020
Shital Rathod1, Arvind Chavhan2, Deepika Ramrao Dharmkare3*, Koustubh Bavdhankar4
{1Associate Professor, 3,4JR3 Medicine, Department Of Medicine} {2Associate Professor, Department Of Paediatrics} Dr. Shankarrao Chavhan Government Medical College , Nanded, INDIA. Email: deepikadharmkare@gmail.com
Abstract Background: Snake-bite is one of the most life-threatening bio-weapon system in the nature which may cause local to systemic complication. Aim: To analyse the outcome of AKI after snake-bite. Material and Methods: A total of 200 patients of either gender with age >12 years having history of snake bite with signs of envenomation were investigated and treated in a tertiary care hospital. Outcome was analysed. Results: Anti-snake venom was given to all cases in the study. Antibiotics, fresh frozen plasma, whole blood and platelets was given to 48%, 19%, 9% and 7.5% cases respectively. Mortality rate among snake bite cases in present study was reported as 2%. and due to snake bite induced AKI was 19%. Conclusion: Mortality rate among snake bite cases was reported as 2% and due to snake bite induced AKI was 19%. Lapse of time in presenting to the hospital is the predictors of poor outcome in snake bite induced acute kidney injury. Early ASV administration and proper supportive management after ASV administration is of utmost importance, for a good patient outcome. Keywords: Snake bite, anti-snake venom, acute kidney injury, mortality
INTRODUCTION Snake-bite is one of the most life-threatening bio-weapon system in the nature which may cause local to systemic complication in the form of neurotoxicity or hematotoxicity. It is a common medical emergency and an occupational hazard especially in tropical countries like India. It is a common occupational hazard mainly in farmers, plantation workers, herders and laborers leading to significant morbidity and mortality that remains largely unreported. The true global burden of snake bite is unknown due to lack of standardized and underreporting. Most snake bites and fatalities occur in Asia, south east, and sub-Saharan Africa, with India reporting the highest mortality due to snake bites.1 Acute kidney injury (AKI) is an important complication of snake bite and a major cause of mortality. AKI is common after bites from myotoxic or haemotoxic snakes. These snakes are Russell’s viper, saw scaled viper, hump nosed pit viper, green pit viper, and sea snake. Hemorrhage, hypotension, disseminated intravascular coagulation (DIC), intravascular hemolysis, and rhabdomyolysis enhance renal ischaemia leading to AKI.2 This study was conducted at tertiary care centre in western Maharashtra, which is one of the fast-growing agricultural areas. The present study was conducted to analyse the outcome of AKI after snake-bite.
MATERIAL AND METHODS The present prospective observational study was conducted in the wards of Department of General medicine at a tertiary care hospital in Maharashtra. All the patients with history of snake bite who fulfilled the inclusion and exclusion criteria, getting admitted at the tertiary care hospital. Sample size A total of 200 snake bite patients were selected by consecutive type of non-probability sampling method. Inclusion criteria
Exclusion Criteria
Methodology Data was collected using a pretested proforma meeting the objectives of the study. Detailed history, physical examination and necessary investigations were undertaken. The purpose of the study was explained to the patient and informed consent was obtained. Using non-invasive methods acute kidney injury in snake bite patients who fulfil the inclusion criteria is assessed. Acute Kidney Injury (AKI) was defined as an “abrupt (within 48 hours) absolute increase in the serum creatinine concentration of ≥0.3 mg/dl from baseline, a percentage increase in the serum creatinine concentration ≥50% or oliguria of 0.5 ml/kg/hr >6 hours. All the patients were managed as per standard hospital protocol and outcome as alive or dead was noted. Laboratory investigations done were Haemoglobin, Total leukocyte count, Platelet count, Whole Blood Clotting Time, Bleeding Time, Blood Urea, Serum Creatinine, Urine Microscopy and Prothrombin Time. USG Abdomen and X-ray Chest were also done whenever necessary. Statistical Analysis The quantitative data was represented as their mean ± SD. Categorical and nominal data was expressed in percentage. The t-test was used for analysing quantitative data, or else non parametric data was analyzed by Mann Whitney test and categorical data was analyzed by using chi-square test. Pearson correlation co-efficient was used for computing correlation between quantitative variables. The significance threshold of p-value was set at <0.05. All analysis was carried out by using SPSS software version 21. RESULTS Incidence of Acute Kidney injury among snake bite cases in present study was reported as 13.5%. In only 4 cases (2%), we were able to identify snake and in all the cases, it was viper snake. Mean age of the study cases was 36.39 years with maximum number of cases i.e. 63% were in active age group of 21-40 years of age. Male predominance was seen in present study with 53% cases as compared to 47% females. Most common occupation among study cases was farming (53%). Most common urinary complaints were hematuria, oliguria (16%) and reduced urinary output (15.5%). Hematological conditions reported in present study were raised PT/ INR (15.5%) and leucocytosis (11.5%). Other conditions seen were anemia (5.5%) and thrombocytopenia (6.5%).
Table 1: Urinary and hematological complaints
RBCs in Urine and raised WBCT were seen in 17% and 18% cases respectively. Raised blood urea at baseline was reported in 11% cases which increased to 15.5% by the end of 24 hours. Mean blood urea was 24.52 mg% at baseline which increases to 28.06 mg%, 31.58 mg% and 34.37 mg% by the end of 24, 48 and 72 hours respectively. Raised serum creatinine at baseline was reported in 14% cases which increased to 16% by the end of 48 hours. Mean s. creatinine was 0.99 mg% at baseline which increases to 1.28 mg%, 1.66 mg% and 2.04 mg% by the end of 24, 48 and 72 hours respectively. Mean urine output was 1533.67 ml at baseline which decreases to 1449 ml by the end of 48 hours. The urine output increases afterward and reached 1608 ml by the end of 72 hours.
Table 2: Laboratory investigations in study subjects
A total of 18% cases reported to hospital within 3 hours after snake bite while 57% reported within 4 to 6 hours. In 3% cases delay was more than 12 hours. Before coming to hospital, 3% cases received anti-snake venom.
Table 3: Distribution of study subjects as per management
Anti-snake venom was given to all cases in the study. Antibiotics, fresh frozen plasma, whole blood and platelets was given to 48%, 19%, 9% and 7.5% cases respectively. Mortality rate among snake bite cases in present study was reported as 2%. Table 4: Distribution of study subjects as per Final Outcome
DISCUSSION Mortality rate among snake bite cases was reported as 2% and mortality among cases with AKI was 19% in the present study. Incidence of Acute Kidney injury among snake bite cases in present study was observed as 13.5%. Asian continent has the highest incidence and in Thailand, Sri Lanka and India, snake bite was complicated by AKI in 5%,3 27%,4 and 13–32%, which is in accordance with the findings of the present study.5,6 The prevalence of AKI in Menon JC et al.7 was 21%, which is slight higher than present study which can attributed to snake species and regional variation. However, results of the present study are comparable to the other reported series in India which are in the range of 13-32%.8,9 Comparable data are available from several other countries as well wherein, the incidence of acute renal failure is ~11%, 6.2%, 5% and 27% in Nigeria, Middle East, Thailand and Ceylon, respectively.10 It has been long believed that Russell’s viper and the saw scaled viper were the species causing AKI in snakebite. Recently, H. hypnale has also reported to be a common cause of AKI by some authors but present study could not evaluate this association as species was identified in only 4 cases although all of the four cases were vipers and also vipers are very commonly found in region of study. In addition to early detection of clinical signs and symptoms of snakebite, early administration of anti-snake venom (ASV) is known to reduce the morbidity and mortality. Anti-snake venom was given to all cases in the study. Antibiotics, fresh frozen plasma, whole blood and platelets was given to 48%, 19%, 9% and 7.5% cases respectively. Indrani D et al..11 ASV was given to 87.88% of cases. In the study of Mahajan and Mhaskar,12 which is in accordance to the present study. 50.66% patients received ASV; whereas in other two other studies,13,14 ASV was given to 90% and 91.7% of patients respectively. Harshavardhana H et al.4 reported that ASV was given to 100% of the cases. Menon JC et al.7 reported (85%) of victims needed ASV and others did not require it and antibiotics, fresh frozen plasma and other treatment was given to patients as required, as in present study. Mortality rate among snake bite cases with AKI was 19% in the present study. Our results are in accordance with Dineshkumar T et al.15 the mortality reported in their study is 15.5% and the risk factors were the presence of coagulopathy and uraemic encephalopathy.
CONCLUSION Mortality rate among snake bite cases was reported as 2% and due to snake bite induced AKI was 19%. Lapse of time in presenting to the hospital is the predictors of poor outcome in snake bite induced acute kidney injury. AKI is an important complication of snake bite that may lead to mortality. Early ASV administration and proper supportive management after ASV administration is of utmost importance, for a good patient outcome. REFERENCES
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