A study of the association of lipid profile and BMI in children

 

 

Abstract               Background: Obesity is a widespread and growing problem in the world with significant medical, psychosocial and economic consequences. Aims and Objectives: To Study association of lipid profile and BMI in Children. Methodology: This was a cross sectional study carried out in the Children and adolescents at tertiary health care centre during the one year period i.e. March 2017 to March 2018, so in the one year period there were 80 patients diagnosed with obesity by Body Mass Index (BMI) Growth charts provided by WHO with respect to age and sex was utilized for inclusion of the individuals. The lipid profile in children was carried out by standard protocol. The data analysis was done by co-relation co-efficient and was done SPSS 19 version software. Result: The average age of the children was 10.22 ± 3.62 Yrs. and range was 2-20 Yrs. The average BMI in Obese children was 25.88±4.41. The majority of the patients were males i.e. 51.25% and females were 48.75% there was Correlation between TG (R2=0.232), LDL (R2=0.633), VLDL (R2=0.238) with respect to BMI (R2=0.009) and no co-relation with HDL (R2 =0.000). Conclusion: It can be concluded from our study that the lipid profile was deranged in children if BMI in children increases so, it indicates that child hood obesity may leads to future cardio vascular diseases.

Key Word: BMI, Lipid profile, Child hood Obesity.

 

 

INTRODUCTION

Obesity is a widespread and growing problem in the world with significant medical, psychosocial and economic consequences.1 Widespread reports indicate that the prevalence of obesity among children and adolescents has been increasing in recent years.2,3 In the US, one-third of overweight Americans are at an increased risk of developing chronic disease such as type 2 diabetes, cardiovascular disease and hypertension.4 In children, the development of obesity is associated with the simultaneous deterioration in chronic disease risk profiles, 5 including adult-onset diabetes mellitus, coronary heart disease and respiratory disease.6 In many studies overweight children had abnormal levels of lipids7,8 and a longitudinal change in relative weight was associated with changes in this risk factors.9

 

METHODOLOGY

 This was a cross sectional study carried out in the Children and adolescents at tertiary health care centre during the one year period i.e. March 2017 to March 2018, so in the one year period there were 80 patients diagnosed with obesity by Body Mass Index (BMI) Growth charts provided by WHO with respect to age and sex was utilized for inclusion of the individuals. The lipid profile in children was carried out by standard protocol. The data analysis was done by co-relation co-efficient and was done SPSS 19 version software.

 

 

RESULT

Table 1: Distribution of the patients as per the age and BMI

The average age of the children was 10.22 ± 3.62 Yrs. and range was 2-20 Yrs. The average BMI in Obese children was 25.88±4.41.

Table 2: Distribution of the patients as per the sex

The majority of the patients were males i.e. 51.25% and females were 48.75%

 

Figure 1: Showing Co-relation of Lipid profile with BMI in children

 

Table 3: Distribution of lipid profile with respect to correlation co-efficient

From above Graph it is clear that there was Correlation between TG (R²=0.232), LDL (R²=0.633),VLDL(R²=0.238) with respect to BMI (R²=0.009) , No correlation with HDL ( R²=0.000).

 

DISCUSSION

Overweight is showing an increasing global trend¹⁰. Current estimates suggest that up to 1.7 billion people are overweight or obese world wide. Obesity is increasing all over the word. Over 115 million people are obese and have problems associated with obesity in developing countries¹¹. Overweight problem is increasing continuously in children and adolescents at an alarming pace^12,13. Cardiovascular diseases are associated with risk factors such as obesity and dyslipidemia, which, if present during infancy, could continue throughout adult life^12,13,14. High serum cholesterol HDL level is associated with longevity as evidence suggest. Low HDL cholesterol level is associated with an increased cardiovascular risk particularly if serum cholesterol and triglycerides are also elevated. The most common primary lipid disorder familial combined hyperlipidemia which is an autosomal dominant condition occurring in 1/200 people could not affect the results of our study with its low incidence. The most common dyslipidemia of obesity is associated with increased triglyceride levels, decreased HDL levels and abnormal LDL cholesterol composition .Accepted risk factors for CVD are elevated LDL and decreased HDL^14,15. The average age of the children was 10.22 ± 3.62 Yrs. and range was 2-20 Yrs. The average BMI in Obese children was 25.88±4.41. The majority of the patients were males i.e. 51.25% and females were 48.75% there was Correlation between TG (R²=0.232), LDL (R²=0.633), VLDL(R²=0.238) with respect to BMI (R²=0.009) and no co-relation with HDL (R² =0.000).

 

CONCLUSION

It can be concluded from our study that the lipid profile was deranged in children if BMI in children increases so, it indicates that child hood obesity may leads to future cardio vascular diseases.

 

REFERENCES

1. Brandini LG. Natural history of obesity. Nestle Nutrition Workshop Series Pediatric Program 2001; 49: 20-22.
2. Troiano RP, Flegal KM. Overweight children and adolescents: description, epidemiology and demographics. Pediatrics 1998; 101: 497-504.
3. Flegal KM, Carroll MD, kuczmarski RJ, Johnson CL.Overweight and obesity in the United States: prevalence and trends, 1960-1994. Int J Obese Relate Metab Disorder 1998; 22:39-47.
4. Troiano RP, Frongillo EA JR, Sobal J,Levitsky DA. The relationship between body weight and mortality: a quantitative analysis of combined information from existing studies. Int J Obese Relat Metab Disorder 1996; 20: 63-75.
5. Gidding SS, Bao W, Srinivasan SR, Berenson GS. Effects of secular trends in obesity on coronary risk factors in children: the Bogalusa heart study. J Pediatr 1995; 127: 868-874.
6. Smoak CG, Burke GL, Webber LS,Harsha DW,Srinivasan SR,Berenson GS. Relation of obesity to clustering of cardiovascular disease risk factors in children and young adults. The Bogalusa Heart study. Am J Epidemiol 1987; 125(3): 364-372.
7. Williams DP, Going SB, Lohman TG, Harsha DW, Srinivasan SR, Webber LS. Body fatness and risk for elevated blood pressure, total cholesterol and serum lipoprotein ratios in children and adolescents. Am J Public Health 1992; 82: 358-363.
8. Laskarzewski P, Morrison JA, Mellies MJ. Relationships of measurements of body mass to plasma lipoprotein in school children and adults. Am J Epidemiol 1980; 111: 395-406.
9.  Freedman DS, Burke GL, Harsha DW,srinivasan SR, Cresanta JL,Webber LS. relationship of changes in obesity to serum lipid and lipoprotein changes in childhood and adolescence. JAMA 1985; 254: 515-520
10.  Suárez, N.P., Prin, M.C., Luciani, S.L., Pilottó, M.T., Dri, M.D. and Politti, I.R. (2008) Prevalencia de factores de riesgo de enfermedad cardiovascular: Obesidad y perfil lipídico. Anales de Pediatría, 68257-68263.
11. de Onis, M. and Blössner, M. (2000) Prevelance and Trends of Overweight among Preschool Children in Developing Countries. American Journal of Clinical Nutrition, 72, 1032-1039.
12. Li, Y., Dai, Q., Jackson, J.C. and Zhang, J. (2008) Overweight Is Associated with Decreased Cognitive Functioning among School-Age Children and Adolescents. Obesity, 16, 1809-1815. http://dx.doi.org/10.1038/oby.2008.296
13. Nascimento, H., Costa, E., Rocha-Pereira, P., Rego, C., Mansilha, H.F., Quintanilha, A., et al. (2012) Cardiovascular Risk Factors in Portuguese Obese Children and Adolescents: Impact of Small Reductions in Body Mass Index Imposed by Lifestyle Modifications. The Open Biochemistry Journal, 6, 43-50. http://dx.doi.org/10.2174/1874091X01206010043
14.  Committee on Nutrition (1998) Cholesterol in Childhood. Pediatrics, 101, 141-147.
15. Pinhas-Hamiel, O., Lerner-Geva, L., Copperman, N.M. and Jacobson, M.S. (2007) Lipid and Insulin Levels in Obese Children: Changes with Age and Puberty. Obesity, 15, 2825-2831.
16. Febrianti, E., Asviandri, null, Farlina, L., Lestari, R., Cahyohadi, S., and Rini, E. (2013). Correlation between lipid profiles and body mass index of adolescents obesity in Padang. International Journal of Pediatric Endocrinology,2013(Suppl 1), P87.doi:10.1186/1687-9856-2013-s1-p87.