AbstractIntroduction: Chronic kidney disease (CKD) an inevitable terminal event of chronic renal parenchymal disease due to various causes is known more for its morbidity than for its mortality. The effects of the altered functioning of the renal system are reflected in every organ system of the body. Aims and Objectives: To Study of Lipid Profile between Conservatively Managed and Hemodialysis Chronic Kidney Disease Patients. Methodology: 100 cases of chronic kidney disease, both males and females, for a period of 1 ½ year admitted in Navodaya Medical College, Hospital and Research Centre, Raichur will be taken for study. Blood: Hb%, TC, DC, ESR., Urine: Albumin, Sugar, Microscopy, Specific Gravity Blood Urea, Serum Creatinine, Fasting & Post prandial blood sugar , Serum electrolytes Lipid profile etc. Investigations carried out. Mean, standard deviation and confidence interval was calculated and the same represented by graphs. Student’s t –test (unpaired t-test) was used to calculate the significance between Conservatively Managed and Hemodialysisgroups. Result: On comparison of chronic kidney disease patients on hemodialysis and conservative treatment there is significant rise in total cholesterol i.e. 196.92 and 176.68 (t = 2.105p<0.021), triglycerides179.78 and 148.6(t = 2.548;p<0.020) , LDL 124.23 and 103.82(1.987 ;p<0.026) , VLDL 35.31 and 28.62(t = 2.548;p<0.016) and Lp(a) 48.43 and 33.87(t = 11.983 p<0.001) Respectively , however HDL cholesterol level were found to be significantly lower in hemodialysis patients as compared to patients on conservative treatment i.e. 37.38 and 44.4(t = 2.260;p<0.027) Conclusion: The hemodialysis in our study seems to derange the lipid profile and enhances atherogenesis in patients, as in comparison of chronic kidney disease, patientsof hemodialysis and conservative treatment there was significant rise in total cholesterol, triglycerides, LDL, VLDL and Lp(a) levels, however HDL cholesterol level were found to be significantly lower in hemodialysis patients as compared to patients on conservative treatment.

Key Words: Chronic Kidney Disease, Lipid Profile, Hemodialysis, Serum Creatnine.