AbstractIntroduction: Arterial stiffness measurement could serve as an important tool in identifying patients at risk of cardiovascular disease and the ability to adentify these patients could lead to better risk stratification and earlier and more effective preventive therapy. Objective: To evaluate arterial stiffness by arterial stiffness index in patients of ischemic heart disease with multiple risk factors like diabetes mellitus, hypertension, dyslipidemia and smoking and comparing it with healthy controls without these risk factors. Methodology: We have studied 30 patients of ischemic heart disease. Any patient of myocardial infarction and angina pectoris is included in our study Diagnosis of IHD was based on symptoms and typical changes in electrocardiogram. This was further conformed by echocardiography whenever necessary. We have studied simultaneously 30 controls. They should have normal blood pressure, blood sugar, lipid profile and should be non smoker with no history of IHD and stroke. Arterial stiffness was measured by arterial stiffness index in all patients by oscillometric method with periscope. Results were compared in these groups by applying unpaired” t” test. Result: It is found that in subjects with ischemic heart disease arterial stiffness index is significantly higher than healthy subjects (P< 0.05). Conclusion: Finally we have concluded that the arterial stiffness index is significantly higher in patients of ischemic heart disease with multiple risk factors like diabetes mellitus, hypertension, smoking and dyslipidemia ( p < 0.05).it is also clear that arterial stiffness index is significantly higher in older age groups i.e.61- 70 years, hence higher risk of coronary artery disease in these age groups.

Keywords: ASI (arterial stiffness index), IHD (ischemic heart disease), HTN (hypertension), DM(diabetes mellitus) ECG(in electrocardiogram).