AbstractIntroduction: The first reported epidemics of dengue or dengue-like disease occurred in 1779 and 1780 in Egypt and Indonesia and in 1780 in the USA (Philadelphia).¹ It is clear that dengue and other arboviruses with similar ecology had a widespread distribution in the tropics as long as 200 years ago. Aims and Objectives: To Study of Serum Aminotransferases Level in Dengue Fever Methodology: The study was performed on patients admitted for dengue fever in Aarupadai Veedu Medical College, Puducherry. Total duration of the study was 2 years. Dengue Serology: Done by immunochromatographic method.AST and ALT was estimated by IFCC (International Federation of Clinical Chemistry) without pyridoxal phosphate activation. Result: It was observed that patients with dengue shock syndrome were in much higher risk for bleeding tendencies as compared to those in the other two groups. It was also observed that patients with secondary dengue infections had a much higher incidence of bleeding as compared to the primary dengue infection of dengue. It was also that the patients who were both secondary infection, they had a higher frequency of hypotension as compared to other group which was only primary infection. It was noted that SGOT and SGPT levels were significantly higher in patients with secondary dengue infection as compared to only primary infection, significant p value (<0.00001). Conclusion: The Secondary Dengue infection was associated with clinical outcomes like higher risk for bleeding tendencies, higher frequency of hypotension, SGOT; SGPT levels were significantly higher in patients with secondary dengue as compared to primary dengue infection.

Keywords: Primary dengue infection, Secondary dengue infection Serum Aminotransferase, Dengue Fever, AST, ALT.