AbstractIntroduction: The prevention or at least control of burn wound sepsis is absolutely vital, if mortality rate in the major thermal burns is to the lowered to an acceptable level. Meticulous surgical cars of the burn wound and intelligent programs of topical therapy have achieved good result in recent years.” Stone H.H. Aims and Objectives: To Study the Role of Amnion as a Biological Dressing on Healing of Wound Due To Burns and Non-Healing Wound. Methodology: Patients of burn wounds and non- healing wounds admitted in Govt. medical college hospital. Aurangabad, over a period of jan.1990 to Jan, 1992 are included in this study. Out of 50 cases studied, 40 cases are of burn and 10 case of non- healing wounds. Placentas from clean vaginal deliveries, emergency and elective caesarian section of sero- negative (non-syphilitic) mothers were collected in sterile bowls. After application of the dressing were amnion, relief of symptoms were asked such as relief of pain, discomfort, improvement in joint movement and sense of well-being. Result: Pain relief, Reduction in discharge, Reduction in size occurred in all 50 cases. The application was done twice and in thirteen cases, three amnion applications were done: all these eighteen cases showed complete healing. In ten superficial wounds, fourth application was needed. Out of these ten cases eight wounds healed completely but in remaining two patients skin grafting was required .There were 20 cases of deep wounds. Out of which none showed any response with single application. Two cases (4%) healed totally following two application of amnion. For the rest eighteen cases, further applications were needed to obtain some conclusive results. With three applications, healthy granulation tissue appeared in two cases (4%). For remaining sixteen (32%) cases. (4%) healed completely and in 14 cases (28%) From the above table, it is seen that 28 superficial wounds healed completely while only in 2 cases the raw area was converted into healthy Granulation. Conclusion: There was prompt clinical response in the form of relief of pain ulcer healing and formation of granulation tissue seen by the application of amnion.

Key Words: Amnion, Burns, Non-Healing Wound.