AbstractIntroduction: Serum uric acid is a biochemical marker in number of diseases, this study is to evaluate association of serum uric acide in acute ischemic stroke. Among all the neurological diseases of adult life, the cerebrovascular ones clearly rank the first in frequency and importance. At least 50% of the neurological disorders in a general hospital are of this type. Stroke, after heart disease and cancer is the most common cause of death. Aims and Objectives: To Study association between Serum Uric Acid (SUA) and acute ischemic stroke. Methodology: A total of 60 patients of either sex were enrolled for the above study. The study was cross sectional. Approval of ethical committee was obtained. Study was carried in Aarupadai Veedu Medical College and hospital, Pondicherry during the period of September 2013 – September 2015. A total of 60 patients (30 males and 30 females) with acute stroke who met the criteria, admitted in Dept. of Medicine, Aarupadai Veedu Medical College, Puducherry were included in this study. All subjects gave informed consent and the study protocol was approved by the Ethical Committee. Result: Majority of this stroke population are between 50 to 69 years old, (61 %) of the population) with 20 Males and 17 females. The elderly population, above 70 years old constitutes 20 % of the population with 5 males and 5females. Hypertension constitutes the major risk factor in this stroke population as 65 % of the population is hypertensive. 20 males and 19 females are hypertensives and form 68 % and 62 % in their respective population. Diabetes mellitus ranks second as a risk factor, constitute 51% of the study population with 14 (46 %) males and 16 (56 %) females. Coronary Artery Disease is associated in 32 % of the population with 9 (30 %) males and 10 (34 %) females. 34 % of the stroke population has adverse lipid profile and both sexes share equal number of hyperlipidemics (10 each). Among the male population, 20 (68 %) are smokers and 10 (32 %) are alcoholics. As per this study; Serum Uric Acid were; Less than 5 mg / dl – 49 % (15 males and 14 females) Between 5 – 6.9 mg / dl - 26 % (8 males and 8 females) Above and equal to 7 mg / dl - 25 % (7 males and 8 females). Conclusion: This study shows that elevated SUA is strongly associated with an increased risk for the development of acute ischemic stroke in this study population.

Key Words: Serum Uric Acid (SUA), acute ischemic stroke.