AbstractBackground and Objectives: Oxytocin is a hormone produced in supraoptic and preventricular nuclei of the hypothalamus and stored in posterior pituitary gland. It acts primarily a neuromodular in the brain. It plays a prime role particularly during and after child birth. Oxytocin is released in large amount after distention of the cervix and uterus during labour and facilitating birth. Hence the purpose of the study was to prove the efficacy and safety of oxytocin 10IU intramuscular administration on reducing the blood loss during third stage of labour. Methods: A prospective observational study was carried out in a teaching hospital. A total of n=112 antenatal cases were studied including both primi and multipara and blood loss measured after delivery of the placenta. Primary end point is measurement of blood loss and secondary end point ranged from severe postpartum haemorrhage (PPH) and maternal mortality and death. Results and Conclusion: Among 112 cases, two participants (1.8%) had PPH and 110 cases had no PPH (98.2%). So our conclude that oxytocin is the best uterotonic drug profile amongst the prophylactic drugs used, which strongly favors its routine use for active management of third stage of labour.

Keywords: Third stage labour, oxytocin, postpartum blood loss, postpartum haemorrhage.