AbstractIntroduction: Cancer of the cervix is a global health problem, comprises approximately 12% of all cancers among women globally. Incidence and mortality of cancer cervix in world is 530232 and 275008 per year while in India it is 134420 and 72825 per year respectively. Aims and Objectives: To study Clinico-Cytological study of the Patients with Malignant Cell on Cervical smear at Tertiary care health care Centre. Material and Method: It is a prospective study of 1386 cases, coming from rural areas. Those cases diagnosed clinically as carcinoma cervix were not included in this study. Papanicolaou stain after wet fixation in 95% ethyl alcohol. Result: Total 25 cases were detected as positive for malignant cells on cervical cytology screening (1.8%). Incidence of smears positive for malignant cells was highest (60%) in the group of 31 to 40 years. In this study no smear was detected positive for malignant cells in patients of age less than 20 years. Incidence of smears positive for malignant cells was higher in multiparas. 16 out of 25 cases belonged to grand multipara (64%). In this study no smears found positive for malignant cells in nuliparous patients. Incidence of smears positive for malignant cells is higher in patients having cervical erosion and chronic vaginal discharge. Incidence of positive smear was higher in patients presenting with post-coital bleeding and chronic vaginal discharge similar incidence was observed in patients having inter-menstrual bleeding. 8% of patient was having no symptoms21 patients of severe dysplasia detected by pap testing were lost to follow up. 11 patient of severe dysplasia were followed up by cervix biopsy. 10 patients were confirmed of severe dysplasia on biopsy and 1 patient showed chronic cervicitis. Conclusion: From our study it can be concluded that Incidence of smears positive for malignant cells was highest (60%) in the group of 31 to 40 years. Incidence of smears positive for malignant cells was higher in multiparas Incidence of smears positive for malignant cells is higher in patients having cervical erosion and chronic vaginal discharge. Incidence of positive smear was higher in patients presenting with post-coital bleeding and chronic vaginal discharge similar incidence was observed in patients having inter-menstrual bleeding. False positive report of cytology for malignant cells was 7.69%.

Keywords: Malignant Cell on Cervical smear, Pap smear, Ca. – Cervix.