AbstracIntroduction: The enterocutaneous fistula (ECF) is a devastating complication for both surgeons and patients alike. Prior to the advent of sophisticated critical care support and parenteral nutrition, the development of an ECF nearly equated to a death sentence. In the current era, the mortality rate has been reduced to 5 to 20%. Aims and Objectives: To Study various factors associated with outcome of Gastro Intestinal Fistula at Tertiary Health care center Methodology: This was a Cross-sectional study of the Patients with Gastro-intestinal fistula at tertiary health care center in 40 patients who developed GI fistulas by various reasons were study during the one year period from December 2014 to December 2015 All those patient those given consent were included into the study while those who didn’t given consent and were having immune compromised state and terminally ill were excluded from the study. All the information related with fistulas and their outcomes were collected by semi structured questionnaire. Result: Thus Ileal site was mostly of high output type and are associated with greater mortality. Perioperative hypotension significantly affecting the mortality thereby close monitoring of IV fluids and judicious use of pressor agents is essential to avoid hypotension. Septicemia significantly affected mortality thereby favoring the pus culture and sensitivity, and antibiotics accordingly covering the wide range of organisms. Mortality was high in Addicted Patients i.e. 26.31% as compared to non- addicted Patients i.e. 19.04%. The most common organism found in the culture was E. coli. Enteral feeding has decreased mortality rate. Conclusion: From our study it can be concluded that the most common factors associated with worse outcome were Ileal site, hypotension, Septicemia and Addiction in the patients.

Keywords: Enterocutaneous fistula (ECF), Gastro Intestinal Fistula, Enteral feeding.