AbstracIntroduction: Measurement of high sensitivity C-reactive protein (hs-CRP) and High-density lipoprotein cholesterol (HDL-C) level both are predictive of future of cardiovascular diseases (CVD). However, studies correlating hs-CRP and HDL-C in South Indian population are scanty. Aims and Objectives: To analyze Correlation of high sensitivity C-reactive protein (hs-CRP) and HDL cholesterol in healthy south Indian individuals. Methodology: This was a retrospective Cross-sectional study carried out at the Department of Cardiology, Chettinad Hospital and Research Institute, Chennai from the medical records of patients evaluated during the period of December 2014 to November 2015 in 990 healthy subjects. This Study was approved by Institutional Ethical Committee. The entire apparently healthy individual were selected from Master Health Check-up for whom hs-CRP and Lipid Profile reports were available. The Persons who were known or suspected to have Cardio Vascular Disease, Hypertension, Diabetes or other infective or inflammatory disorders were excluded from the Study. The Statistical Analysis was done by SPSS Software, Pierson Correlation was applied for Correlation between hs-CRP and HDL-C and the Correlation coefficient R were calculated. Result: There is negative correlation is seen between HDL and hs-CRP and the Pearson Correlation coefficient R= -0.089and the negative correlation is statistically significant (P< 0.01*) Conclusion: It is found that there is negative correlation is observed between HDL and hs-CRP so it can be concluded that the hs-CRP can be an independent risk factor and has added predictive value in determining the risk of cardio vascular diseases.

Key Words: high sensitivity C-reactive protein (hs-CRP), HDL cholesterol.