AbstractBackground: Chronic irritation of eyes is a distressing situation for both the patient and doctor. It is caused by a group of conditions and diseases. Aim: This study was done to find out the various causes of chronic irritation of eyes among patients attending eye OPD, Pandit Deen Dayal Upadhyay Hospital attached to SMS Medical College and Hospital, Jaipur and to find out the association between Meibomitis and Blepharitis with dry eye. Material and Method: The duration of study is 6 months. It is prospective type of study comprised 1000 patients who were suffering from chronically irritated eye presented to the Eye OPD, Pandit Deen Dayal Upadhyay Hospital attached to SMS Medical College and Hospital, Jaipur after applying exclusion criteria. Results: In the case series, out of 1000 cases 536 (53.6%) were males and 464 (46.4%) were females. The male to female ratio was 1:15. It was observed that in IVth and Vth decade, there was female dominance who were affected by chronically irritant eyes. There was male dominance in between 10 years to 40 years and it can be explained by the fact that in this age group is more exposed to computer and outdoor environment. We found out that maximum number of patients belong to II half of age group (72%). In our study 534 (53.4%) patient belong to rural background and 466 (46.6%) belong to urban background. The most common occupational group affected was agricultural workers group (29.2%) followed by manual labourers (26.5%) and then by office workers 184 (18.4%). In our study we find out the most common cause of chronic eye irritation was Allergic conjunctivitis 278 (27.8%), followed by Meibomitis 236 (23.6%), Dry eye 210 (21%), Blepharitis 90 (9%), Chalazion 12 (1.2%), Pterygium 50 (5%), VKC 42 (4.2%), Prolonged use of topical drugs 23 (2.3%) and prolonged computer work 59 (5.9%). We also observed that Meibomitis and Blepharitis were associated dry eye in 31.77% and 41.1% patients respectively. Conclusion: Highest prevalence 63.9% of chronic irritation of eyes seen in age group (40-69 years). There was no age group debarred from this disease. We find out allergic conjunctivitis 278 (27.8%) is the most common cause followed by Meibomitis 236 (23.6%) and it is associated with dry eye.