AbstractObjective: To study if there is any association between gestational diabetes mellitus with hypothyroidism in primi gravida. Methods: Between June 2014 and May 2015, serum thyrotropin (TSH) screening was performed on all primi gravida who presented for prenatal care. Women identified with elevated thyrotropin level were considered hypothyroid. Out of these 60 women were randomly selected and subjected to oral glucose tolerance test with 75gm oral glucose according to DIPSI guidelines. Along with the hypothyroid cases 60 primi gravida with normal Serum TSH level were also subjected to the oral glucose tolerance test which would act as the control group for the analysis. For this analysis normal thyrotropin values were taken as 0.2 to 3mIU/L as per American Thyroid Association guidelines¹. The incidence of gestational diabetes mellitus was compared between the study and the control group. Results: Of the 120 women included in the study 60 were euthyroid, 60 were hypothyroid. Gestational diabetes was more in the hypothyroid group than in the control group. Conclusion: The risk of developing gestational diabetes increases with hypothyroidism. This supports association between hypothyroidism and diabetes, diagnosed during pregnancy.

Key Word: Gestational diabetes mellitus, hypothyroidism, Diabetes In Pregnancy Study Group India, Oral Glucose Tolerance Test, Thyroid Stimulating Hormone, Decreased Gestational Glucose Tolerance.