AbstractIntroduction: Non-alcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease worldwide. Non-alcoholic fatty liver disease has been increasingly recognized as the most common pathological condition affecting liver. The metabolic syndrome including dyslipidemia, impaired glucose tolerance, hypertension and obesity has significant relationship with non-alcoholic fatty liver disease. So in this study we compared the Body Mass index (BMI), the levels of serum aminotransferases and other biochemical parameters of patients with non-alcoholic fatty liver detected by ultrasonography (USG). We also studied the risk factors associated with enzyme derangements in non-alcoholic fatty liver disease. Materials and Methodology: Patients who were clinically suspected to have fatty liver, screened using ultrasound and diagnosed to have non-alcoholic fatty liver disease,were included in the study from April 2016 to June 2016. Other causes of fatty liver were ruled out. Biochemical assays were performed for aspartate aminotransferase (AST), alanine aminotransferase (ALT), Fasting Blood Sugar (FBS), Total cholesterol (CHL), triglycerides (TG), low density lipoprotein (LDL) and Thyroid stimulating Hormone (TSH). The fatty liver was graded based on the USG. Results: Total number of patients were eighty one including 45 males (56 %) and 36 females (44 %) aged between 20 to 65 years. Most patients in our study were 30 to 50 years old, with median age of 42.8± 9.7 years and most of them had grade 1 fatty liver by ultrasonography. In our study there was significant relation between aminotrasferase (ALT) and Lipid profile (cholesterol, triglyceride and LDL) with a P value of < 0.01. We compared ALT with BMI and fasting blood sugar which yielded a significant P value of <0.01 and <0.05 respectively. There was statistically significant positive correlation between increased ALT and TSH (p<0.001). Conclusion: Patients with NAFLD, who had high Body mass index, elevated lipid profile and increased fasting blood glucose were found to exhibit increased levels of alanine aminotransferase. Further, although patients were not known to have underlying comorbids such as diabetes, hypertension and dyslipidemia, they were detected to have increased BMI, fasting blood glucose, and elevated lipids, which represents part of the metabolic syndrome.

Keywords: Non alcoholic fatty liver disease, aminotransferases,body mass index, cholesterol, triglyceride, low density lipoprotein, ultrasonography.