Official Journals By StatPerson Publication
Table of Content - Volume 11 Issue 1 -July 2019
Madhura Katdare1, Sandip Agarkar2*
1Associate Professor, 2Assisstant Professor, Department of Anaesthesiology, Government Medical College, Akola, Maharashtra, INDIA. Email: sandip.agarkar@gmail.com
Abstract Background: Middle ear surgeries have made a significant progress with the usage of the operating microscope, which magnifies the surgical field many times; however, it also magnifies the blood droplets and thus obscure the surgical field. many pharmacological agents are used to provide oligaemc field. Aims and Objectives: The present study was done to compare the effect of oral premedication with clonidine and Metoprolol on intraoperative hemodynamics .Methodology: After the Ethics committee approval and informed consent, 50 patients, age group 19-60 years, ASA Grade 1 and 2 for microscopic ear surgery were included into the study carried out at department of Anesthesia of a tertiary health care centre. A Randomized prospective double blind study with 2 groups (25 patients in each group) was conducted: Group Clonidine: Patient receiving Oral Clonidinein a dose of 150 µg, Group Metoprolol: Patient receiving oral Metoprolol 50 mg, both 90 minutes preoperatively. The statistical analysis was done by unpaired t-test and calculated by SPSS 18 version software. Result: Peri- operative mean arterial blood pressure was compared to its basal values in both the groups. Pre–op and 15 min values were comparable. Metoprolol group showed significantly lower MAP at 30-45 60minutes only. Heart rate: Metoprolol group observed a lower Heart rate than Clonidine group with statistically significant (p<0.05) difference at 1,5,30,45,60,75 and 90 minutes intraoperatively. Conclusion: It can be concluded from our study that oral metoprolol was better as compared to oral clonidine with respect to vital parameters like Heart rate and MAP, etc. Key Word: Clonidine, metoprolol, Hemodynamic stability (Vital Parameter).
INTRODUCTION Middle ear surgeries have made a significant progress with the usage of the operating microscope, which magnifies the surgical field many times; however, it also magnifies the blood droplets and thus a small amount of blood can obscure the surgical field. Conventional microscopic ear surgery (MES) using a post-auricular approach remains the most common tympanoplasty technique. There are several pharmacological and non-pharmacological techniques for an appropriate control of intra operative bleeding. The non-pharmacological (mechanical) methods for deliberate hypotension include positioning the patient and IPPV to control venous return. Several pharmacologic agents have been used to produce oligaemic surgical field in microscopic ear surgery. Direct vasodilators as nitroprusside16 and nitroglycerine, alpha-2 adrenergicagonistsas clonidine and dexmedetomidine, beta adrenergic antagonists as propranolol, metoprolol esmololinhalational anaesthetics as is of lurane and sevoflurane, μ-receptors agonist as remifentanil, and N-methyl d-aspartate antagonist as magnesium were used to decrease intraoperative bleeding during middle ear surgery Inappropriate bleeding is one of the complications of ear surgeries because it can lead to poor visibility for the surgeon and visibility is further reduced the longer the time of the intervention is extended. Increased bleeding can also cause surgeons to abandon procedures before they are fully completed. Improvement of intraoperative visibility by reducing bleeding is an important task for an anaesthetist during head and neck surgery.12,13,14,15 Studies show that using beta-blockers before surgery reduces long term cardiovascular complications and intraoperative bleeding18,19. The probable mechanism of beta-blockers in hemodynamic control is a reduction and attenuation of the excitatory effect caused by a sudden increase of catecholamine during surgery. It is believed that beta-blockers are responsible for improvement of the cardiovascular condition and patients’ hemodynamic stability via changes in stress related physiological response18,22. Clonidine and Metoprolol are commonly used drugs for providing oligaemic field. In this study we have compared the effect of these drugs used orally as pre-medicants for decreasing intraoperative bleeding on the haemodynamic variables during microscopic middle ear surgery Clonidine, a centrally acting alpha2 adrenergic agonist, which was first introduced into clinical practice as an antihypertensive medication, has been recently used for anaesthetic premedication, providing sedative, anxiolytic, and analgesic effects. Clonidine also attenuates hypertension, tachycardia, and nor-epinephrine release in response to stress. Clonidine is an α–2 adrenoreceptor agonist. It exerts central sympatholytic effect and has a half-life of 9-12 h6 Premedication with clonidine blunts the stress response to surgical stimuli and the narcotic and anaesthetic doses are also reduced. In addition, clonidine increases cardiac baroreceptor reflex sensitivity to increase in systolic blood pressure, and thus stablises, blood pressure11 Metoprolol is a selective beta-adrenergic blocker without intrinsic sympatheticomimetic activity. In high doses it may act upon b1 and b2 receptors. It is available for intravenous administration and is perioperatively used to control hypertension and tachyarrthmias. After intravenous administration, its peak of action occurs in approximately ten minutes and its elimination half-life is 3 to 4 hours. It has a high distribution volume of 5 to 6 L.kg-1, suffers liver metabolization and its inactive metabolites are excreted by urine and feces. Hemodynamic effects are negative chronotropism and inotropism without significant vascular resistance changes 19. b1-blocker recovery pharmacodynamics is prolonged and may last more than 12 hours after excessive doses.
METHODOLOGY After the ethics committee approval and informed consent, 50 patients, age group 19-60 years, ASA Grade 1 and 2 for microscopic middle ear surgery were included into the study carried out at department of Anesthesia of a tertiary health care centre. A Randomized prospective double blind study with 2 groups (25 patients in each group) was conducted: Group I Clonidine: Patient receiving Oral Clonidine in a dose of 150 µg, Group II Metoprolol: Patient receiving oral Metoprolol50 mg, both 90 MINUTES prior to surgery. The patients with age between 18-60 years., ASA Grade 1 and 2, were included into the study while, patient who didn’t given consent, ASA Grade 3and 4, hypertensive patients/other ECG changes Asthmatics, Baseline pulse <55/systoloic BP <100 mm Hg, H/o Bleeding disorder were excluded from the study. All the patients with written and explained consent underwent General anesthesia with standard anesthetic protocol. Patients were premedicated with IV ranitidine 50 mg, ondansetron 4 mg, midazolam 1 mg Following preoxygenation for 3 min, anesthesia was induced with IV fentanyl 2 µg/kg and Propofol 2 mg/kg. Tracheal intubation was facilitated with suxamethonium 2 mg/kg. Anesthesia was maintained with O2and N2O 50:50, isoflurane up to 1.2 Vol% and Vecuronium 0.02mg/kg to maintain EtCO2 between 30 and 40 mmHg All patients received lactated Ringer lactate solution at approximately 10 ml/kg/h during 1st h of anesthesia followed by 5 ml/kg/h until the end of surgery. The heart rate (HR) and Mean Arterial blood pressure (MAP) were measured non-invasively by an oscillometric device before induction and thereafter every 15 min up to 105mins. All the vital parameters like HR, MAP were noted and the statistical analysis was done by unpaired t-test and calculated by SPSS 18 version software. On completion of surgery, nitrous oxide and isoflurane were discontinued, and lungs were ventilated with 100% oxygen. Residual neuromuscular blockade was antagonized with neostigmine 2.5 mg and glycopyrrolate 0.5 mg and trachea were extubated following usual extubation criteria. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), MAP, SpO2, and EtCO2 were monitored. RESULT Table 1: Age and Weight distribution between groups
The mean age and weight were compared by t-test. No significant difference is present between groups with regard to the age and weight of patient. Table 2: Sex distribution between Groups
The study conducted of two groups; Group Metoprolol and Group Clonidine, with 25 patients undergoing Microscopic middle ear surgeries in both the groups (n=25 in each group). Fisher’s test shows no significant difference in the sex of the two groups . Table 3: Distribution of the patients as per the MAP
When MAP was compared in the two groups, the basal and 15, min values were comparable. There was a statistically significant difference (p<0.05) in MAP at 30 45, 60min min interval between the two groups with lower values in Group II Metoprolol group. There was no significant difference between groups at 75, 90 and 105 mins (P > 0.05) Table 6: Distribution of the patients as per the Mean Heart Rate (HR)
The Pre-OP HR was 75.84±3.12 and 76.12±2.43 was comparable (p>0.05).There was a statistically significant difference in Heart rate in the two groups at15,30,45,60,75 and 90 mins with p values <0.05and highly significant difference observed at 45 mins, majority of patients in Group II Metoprolol group observed a lower Heart rate than Group I Clonidine group. There was no statistically significant difference in Heart Rate at 105 mins towards end of surgery.
DISCUSSION It has been postulated that reduction of MAP during general anesthesia (GA) can minimize intra operative bleeding2,3. However studied shave demonstrated that MAP and total blood loss are not necessarily correlated. Improved surgical field with a beta blocker has been attributed to vasoconstriction of the mucous membrane arterioles and pre-capillary sphincters resulting from unopposed alpha adrenergic effects of endogenous catecholamines5 and solely on the effect of MAP. The effect of clonidine given as an oral pre-anesthetic medication in producing a bloodless surgical field in patients undergoing middle ear surgery was examined by Marchal et al3 and the patients received clonidine (300 mcg/oral) 90 min prior to surgery. In the study by Nair et al8 they found a correlation between HR and surgical field grade and they observed a better surgical field with a reduction in HR. The metoprolol group had a significantly lower HR than the placebo group. Premedication with oral clonidine reduced intra operative bleeding and decreased Isoflurane, fentanyl, requirement for achieving controlled hypotension in patients undergoing middle ear surgery2. Nitu Puthenveettil22 they found Metoprolol patients showed a statistically lower HR from pre-induction up to 90 min while systolic BP (SBP), diastolic BP (DBP) and mean arterial pressure did not show a significant difference. In our study we have seen that the mean age and weight were compared by t-test. No significant difference is present between groups with regard to the age and weight of patient. In our study we found that patients in Metoprolol group had significantly lower Heart rate as compared to Clonidine group intra operatively. Also the MAP was significantly lower in Metoprolol group only for initial one hour (between 30-60 mins), otherwise all readings were comparable. The reduction in MAP with Metoprolol was limited only during first half hour of surgery but had no significant effect thereafter as compared to Clonidine group.
CONCLUSION It can be concluded from our study that oral metoprolol used 90 minutes preoperative was better as compared to oral clonidine with respect to vital parameters like Heart rate and Mean Arteial Pressure, etc.
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