AbstractIntroduction: Metabolic encephalopathy is a transient cerebral dysfunction which may cause temporary or permanent damage to the brain due to lack of glucose, oxygen or other metabolic agent. Most of the cases occur when the liver cannot function normally to remove toxins from the bloodstream during an acute illness, but it can also be caused by other systemic diseases especially renal disease and endocrine disease Aims and Objectives: Study of Identification of Poor Prognostic Factors in Metabolic Encephalopathy. Methodology: This is a cross sectional study including 100 patients with metabolic encephalopathy satisfying inclusion criteria. Cases admitted in the Medical Intensive care unit (MICU) of Aarupadai Veedu Medical college hospital and diagnosed as metabolic encephalopathy from June 2013 to May 2015 were included in the present study. Chi –square test was used by statistical significance Result: The variables identified as poor prognostic factors were Age >60; OR 3.1 (2.85-6.56).Female; OR 1.5(1.45-8.6). H/O Chronic Liver Disease; OR 2.5(2.32-5.6).Ascites; OR 2.87 (2.2-4.5). Jaundice; OR 2.92 (2.25-5.45) and Dys-electremia OR 3.1(2.95-6.67). ESR ≥ 34 OR 1.2(1.1-4.32). Cirrhosis on USG OR3.2 (2.85-5.62). AST: ALT ≥ 2.1 OR 3.5(2.82-6.62). Total Bilirubin≥4 OR 2.75(2.12-6.65). In outcome of the patients Improved 65% and Recovered completely in 15%, Discharge against Medical Advise 7%; Death occurred in 13% the most common factors associated like Age >60 Female, Chronic Liver Disease, Ascites, Jaundice, Dys-electremia, ESR ≥ 34, Cirrhosis on USG AST: ALT ≥ 2, Total Bilirubin≥4. Conclusion: The poor prognostic factors identified in our study were Age >60 Female, Chronic Liver Disease, Ascites, Jaundice, Dys-electrolemia, ESR ≥ 34, Cirrhosis on USG AST: ALT ≥ 2, Total Bilirubin≥4 these poor prognostic factors were mostly associated with death.

Keywords: Metabolic Encephalopathy, Chronic Liver Disease, Ascites, Jaundice, Dys-electremia, ESR.